Phenotypes associated with this allele

• Allele Symbol: Trpm3^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528836
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm3^tm1Lex/Trpm3^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:6727363
hm2	Trpm3^tm1Lex/Trpm3^tm1Lex	involves: 129S/SvEvBrd * C57BL/6J	MGI:5433500
ht3	Trpm3^em1Alsh/Trpm3^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J * CBA	MGI:6727361

Genotype
MGI:6727363

hm1

• Allelic Composition: Trpm3^tm1Lex/Trpm3^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:307352 )

N • transparent lens

small lens ( J:307352 )

microphthalmia ( J:307352 )

mortality/aging

mortality/aging ( J:307352 )

N • viable

reproductive system

reproductive system phenotype ( J:307352 )

N • fertile

growth/size/body

growth/size/body region phenotype ( J:307352 )

N • no gross abnormalities

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
microphthalmia		DOID:10629		J:307352

Genotype
MGI:5433500

hm2

• Allelic Composition: Trpm3^tm1Lex/Trpm3^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

nervous system

abnormal sensory neuron physiology ( J:174798 )

• the fraction of pregnenolone sulfate (PS) sensitive neurons is drastically reduced in the dorsal root ganglia and trigeminal ganglia and PS stimulation fails to induce inward currents in patch clamp assays

• moderate but significant reduction in the heat sensitivity (43^oC) of dorsal root ganglia and trigeminal ganglia neurons with a strong reduction in the population of cells responsive to both PS and heat

behavior/neurological

abnormal thermosensation ( J:174798 )

• during the first 30 minutes of a thermal preference assay mice spend more time at temperatures between 31 and 45^oC compared to controls

• however, over the duration of the assay thermal preference is similar to controls

increased chemical nociceptive threshold ( J:174798 )

• injection of pregnenolone sulfate (PS) into the plantar skin of the hindpaw does not evoke any nocifensive behavior (paw licking and lifting)

• lack an aversive response to the presence of PS in drinking water

• response to hindpaw injection of capsaicin is normal

abnormal nociception after inflammation ( J:174798 )

• injection of complete Freund's adjuvant fails alter hot plate withdrawal

increased thermal nociceptive threshold ( J:174798 )

• strongly increased tail flick latencies in a tail immersion assay and longer delays in a hot plate assay at 52 - 58^oC

Genotype
MGI:6727361

ht3

• Allelic Composition: Trpm3^em1Alsh/Trpm3^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

vision/eye

abnormal iris pigment epithelium ( J:307352 )

• partial adhesion to anterior lens surface

abnormal lens morphology ( J:307352 )

• accumulation of nucleated cells in and around lens from equator to posterior pole

• partial adhesion of iris pigment epithelium to anterior lens surface

• progressive lens fiber cell degeneration

• progressive calcium accumulation

• progressive accumulation of myofibroblast- and macrophage-like cells, especially in anterior pyramidal cataract region

abnormal lens capsule morphology ( J:307352 )

• thickened, folded or wrinkled in anterior pyramidal cataract region

• normal in equatorial region

abnormal lens epithelium morphology ( J:307352 )

• abnormal multi-layering of anterior epithelium

abnormal lens topology ( J:307352 )

• anterior displacement of lens nucleus

anterior polar cataract ( J:307352 )

• fibrotic pyramidal cataract

• progressive calcium accumulation

small lens ( J:307352 )

microphthalmia ( J:307352 )

pigmentation

abnormal iris pigment epithelium ( J:307352 )

• partial adhesion to anterior lens surface

reproductive system

reproductive system phenotype ( J:307352 )

• fertile

mortality/aging

mortality/aging ( J:307352 )

• viable

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:307352
microphthalmia		DOID:10629		J:307352