Phenotypes associated with this allele

• Allele Symbol: Trpm1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528857
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm1^tm1Lex/Trpm1^tm1Lex	involves: 129S/SvEvBrd	MGI:4412009
ht2	Trpm1^tm1Lex/Trpm1^tvrm27	involves: 129S/SvEvBrd * C57BL/6J	MGI:5568986

Genotype
MGI:4412009

hm1

• Allelic Composition: Trpm1^tm1Lex/Trpm1^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye physiology ( J:154776 )

• rod bipolar cell response is absent in mutants in response to chemically-stimulated light responses

• about 50% of cone ON-bipolar cells show no response to chemical stimulation by alpha-cyclopropyl-4-phosphonophenylglycine (CPPG) and the remaining cells activate a small transient current

abnormal eye electrophysiology ( J:154776 )

• spatial frequency and contrast sensitivity thresholds of the optokinetic response (OKR) are reduced 10% and 3-fold respectively compared to wild-type mice

• b-wave and oscillatory potentials are absent from both rod- and cone-mediated (scotopic and photopic) electroretinograms of mutants, whereas a-waves are identical to controls

• rod bipolar cell response is absent in mutants

• a capsaicin-sensitive current is present in some ON-bipolar cells in the mutant retina, but the magnitude is somewhat reduced compared to wild-type

abnormal cone electrophysiology ( J:154776 )

abnormal rod electrophysiology ( J:154776 )

abnormal vision ( J:154776 )

• vision is impaired as indicated by results of optokinetic response (OKR) tests, although not profoundly so

Genotype
MGI:5568986

ht2

• Allelic Composition: Trpm1^tm1Lex/Trpm1^tvrm27
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

vision/eye

abnormal rod electrophysiology ( J:209941 )

• no b-wave in dark-adapted mice