Phenotypes associated with this allele

• Allele Symbol: Mcam^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528863
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mcam^tm1Lex/Mcam^tm1Lex	involves: 129S/SvEvBrd	MGI:5477916

Genotype
MGI:5477916

hm1

• Allelic Composition: Mcam^tm1Lex/Mcam^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased macrophage cytokine production ( J:193167 )

• 2-fold lower production of CXCL1 in isolated alveolar macrophages 4 hours after Mycoplasma pneumoniae infection

• isolated alveolar macrophages from naive mice stimulated with a TLR2 agonist (Pam2CSK4) produce less CXCL1

abnormal cytokine level ( J:193167 )

• at 4 hours after Mycoplasma pneumoniae infection levels of CXCL1 in BAL fluid and lung tissues are reduced compared to wild-type controls

• however, the difference is gone by 24 hours after infection

abnormal response to infection ( J:193167 )

• at 4 hours after Mycoplasma pneumoniae infection levels of CXCL1 in BAL fluid and lung tissues are reduced compared to wild-type controls

• however, the difference is gone by 24 hours after infection and bacterial load is similar to controls

homeostasis/metabolism

abnormal cytokine level ( J:193167 )

• at 4 hours after Mycoplasma pneumoniae infection levels of CXCL1 in BAL fluid and lung tissues are reduced compared to wild-type controls

• however, the difference is gone by 24 hours after infection

hematopoietic system

decreased macrophage cytokine production ( J:193167 )

• 2-fold lower production of CXCL1 in isolated alveolar macrophages 4 hours after Mycoplasma pneumoniae infection

• isolated alveolar macrophages from naive mice stimulated with a TLR2 agonist (Pam2CSK4) produce less CXCL1