Phenotypes associated with this allele

• Allele Symbol: Rtn2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528884
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rtn2^tm1Lex/Rtn2^tm1Lex	involves: 129S/SvEvBrd	MGI:4438740
ht2	Rtn2^tm1Lex/Rtn2^+	involves: 129S/SvEvBrd	MGI:4438739

Genotype
MGI:4438740

hm1

• Allelic Composition: Rtn2^tm1Lex/Rtn2^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:158249 )

N • skeletal muscle cells exhibit normal calcium ion release, twitch tension, time to peak, half relaxation time, and 125 Hz-induced submaximum tension and frequency-tension relationship

decreased skeletal muscle cell glucose uptake ( J:158249 )

• exercise-induced glucose uptake in skeletal muscle cells is seriously impaired compared to in wild-type mice

• however, insulin-induced glucose uptake is normal

homeostasis/metabolism

abnormal circulating glucose level ( J:158249 )

• long-lasting electrical stimulation of hindlimbs fails to change blood glucose unlike in wild-type mice

cellular

decreased skeletal muscle cell glucose uptake ( J:158249 )

• exercise-induced glucose uptake in skeletal muscle cells is seriously impaired compared to in wild-type mice

• however, insulin-induced glucose uptake is normal

Genotype
MGI:4438739

ht2

• Allelic Composition: Rtn2^tm1Lex/Rtn2⁺
• Genetic Background: involves: 129S/SvEvBrd

muscle

decreased skeletal muscle cell glucose uptake ( J:158249 )

• exercise-induced glucose uptake in skeletal muscle cells is abolished compared to in wild-type mice

cellular

decreased skeletal muscle cell glucose uptake ( J:158249 )

• exercise-induced glucose uptake in skeletal muscle cells is abolished compared to in wild-type mice