Phenotypes associated with this allele

• Allele Symbol: Mchr1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528891
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mchr1^tm1Lex/Mchr1^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3797505

Genotype
MGI:3797505

hm1

• Allelic Composition: Mchr1^tm1Lex/Mchr1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:136869 )

• reduced anxiety-like behavior in open field activity and in elevated plus maze

• significantly reduced stress-induced hyperthermia

• no impact on embryonic viability and the animals appeared grossly normal

decreased response to stress-induced hyperthermia ( J:136869 )

• significantly reduced stress-induced hyperthermia

abnormal social investigation ( J:136869 )

• increased social interaction with an intruder-interactor mouse

homeostasis/metabolism

decreased response to stress-induced hyperthermia ( J:136869 )

• significantly reduced stress-induced hyperthermia

increased body temperature ( J:136869 )

• significantly higher basal resting temperature

decreased serotonin level ( J:136869 )

• significantly lower extracellular serotonin in the prefrontal cortex

adipose tissue

decreased percent body fat/body weight ( J:185494 )