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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Padi2tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528933
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Padi2tm1Lex/Padi2tm1Lex B6.129S5-Padi2tm1Lex MGI:5451196
hm2
 		Padi2tm1Lex/Padi2tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5461061


Genotype
MGI:5451196
hm1
Allelic
Composition		 Padi2tm1Lex/Padi2tm1Lex
Genetic
Background		 B6.129S5-Padi2tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi2tm1Lex mutation (1 available); any Padi2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:190651 )
• mast cells exhibit impaired ATP- or calcium ionophore ionomycin-induced citrullination compared with wild-type cells
• however, mast cells exhibit normal degranulation and cytokine secretion

hematopoietic system
abnormal mast cell physiology ( J:190651 )
• mast cells exhibit impaired ATP- or calcium ionophore ionomycin-induced citrullination compared with wild-type cells
• however, mast cells exhibit normal degranulation and cytokine secretion




Genotype
MGI:5461061
hm2
Allelic
Composition		 Padi2tm1Lex/Padi2tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi2tm1Lex mutation (1 available); any Padi2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:190651 )
• following induction of experimental autoimmune encephalomyelitis (EAE), MOG-treated mice exhibit no citrullination of proteins unlike control mice
• however, mice exhibit normal susceptibility to and development of EAE




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory