About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Padi2tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528933
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Padi2tm1Lex/Padi2tm1Lex B6.129S5-Padi2tm1Lex MGI:5451196
hm2
 		Padi2tm1Lex/Padi2tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5461061


Genotype
MGI:5451196
hm1
Allelic
Composition		 Padi2tm1Lex/Padi2tm1Lex
Genetic
Background		 B6.129S5-Padi2tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi2tm1Lex mutation (1 available); any Padi2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:190651 )
• mast cells exhibit impaired ATP- or calcium ionophore ionomycin-induced citrullination compared with wild-type cells
• however, mast cells exhibit normal degranulation and cytokine secretion

hematopoietic system
abnormal mast cell physiology ( J:190651 )
• mast cells exhibit impaired ATP- or calcium ionophore ionomycin-induced citrullination compared with wild-type cells
• however, mast cells exhibit normal degranulation and cytokine secretion




Genotype
MGI:5461061
hm2
Allelic
Composition		 Padi2tm1Lex/Padi2tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi2tm1Lex mutation (1 available); any Padi2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
autoimmune response ( J:190651 )
• following induction of experimental autoimmune encephalomyelitis (EAE), MOG-treated mice exhibit no citrullination of proteins unlike control mice
• however, mice exhibit normal susceptibility to and development of EAE




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory