All Phenotypes Rgs11<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rgs11^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528953

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs11^tm1Lex/Rgs11^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609693
cx2	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1Cjch/Rgs7^tm1Cjch	involves: 129S5/SvEvBrd * C57BL/6	MGI:5426907
cx3	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1.1Kama/Rgs7^tm1.1Kama	involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL	MGI:5427735
cx4	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1Lex/Rgs7^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3850242

Allelic Composition	Rgs11^tm1Lex/Rgs11^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11^tm1Lex mutation (2 available); any Rgs11 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cone electrophysiology ( J:150122 )

• the leading and trailing edges for the average b-wave response from the cone-isolated b-wave is delayed and the amplitude is increased compared to in wild-type mice

• photopic b-wave electroretinogram responses are delayed compared to in wild-type mice

• however, photoreceptor-derived a-waves are normal

abnormal rod electrophysiology ( J:150122 )

• scotopic b-wave electroretinogram responses are delayed compared to in wild-type mice

• negative- and positive-scotopic threshold responses are reduced compared to in wild-type mice

• however, photoreceptor-derived a-waves are normal

Allelic Composition	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1Cjch/Rgs7^tm1Cjch
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11^tm1Lex mutation (2 available); any Rgs11 mutation (31 available)
Rgs7^tm1Cjch mutation (0 available); any Rgs7 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Rgs7^tm1Cjch/Rgs7^tm1Cjch Rgs11^tm1Lex/Rgs11^tm1Lex mice have no ERG b-waves and contain ultrastructural defects in the retinal outer plexiform layer

mortality/aging

mortality/aging ( J:184922 )

N	• normal viability

reproductive system

reproductive system phenotype ( J:184922 )

N	• normal fertility

vision/eye

abnormal retina outer plexiform layer morphology ( J:184922 )

• fewer triads per spherule compared to in wild-type mice

• fewer spherules with ribbons compared to in wild-type mice

abnormal cone electrophysiology ( J:184922 )

• absent b-wave under scotopic and photopic conditions

abnormal rod electrophysiology ( J:184922 )

• absent b-wave under scotopic and photopic conditions

Allelic Composition	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1.1Kama/Rgs7^tm1.1Kama
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11^tm1Lex mutation (2 available); any Rgs11 mutation (31 available)
Rgs7^tm1.1Kama mutation (0 available); any Rgs7 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal rod electrophysiology ( J:184794 )

• mice lack dark-adapted electroretinogram b-wave

nervous system

abnormal single cell response ( J:184794 )

• rod ON bipolar cells lack a flash response and exhibit a 40-folder shorter light-evoked response compared with wild-type cells

Allelic Composition	Rgs11^tm1Lex/Rgs11^tm1Lex Rgs7^tm1Lex/Rgs7^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs11^tm1Lex mutation (2 available); any Rgs11 mutation (31 available)
Rgs7^tm1Lex mutation (2 available); any Rgs7 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal eye electrophysiology ( J:150122 )

• mice exhibit additive effects on time course of the dark-adapted electroretinogram responses arising from bipolar cells

abnormal rod electrophysiology ( J:150122 )

• negative-scotopic threshold response is reduced compared to in wild-type mice or single mutants

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