Phenotypes associated with this allele

• Allele Symbol: Rgs14^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528963
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs14^tm1Lex/Rgs14^tm1Lex	involves: 129S/SvEvBrd * C57BL/6	MGI:4838401
hm2	Rgs14^tm1Lex/Rgs14^tm1Lex	involves: 129S5/SvEvBrd	MGI:3609690

Genotype
MGI:4838401

hm1

• Allelic Composition: Rgs14^tm1Lex/Rgs14^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:164681 )

N • mice exhibit normal sensory-motor-gating

abnormal action potential ( J:164681 )

• CA2 neurons exhibit more action potential spikes following stimulation compared with similarly treated wild-type neurons

abnormal neuron physiology ( J:164681 )

• CA2 neurons exhibit increased input resistance compared with wild-type cells

abnormal synaptic plasticity ( J:164681 )

• synaptic plasticity in CA2 neurons is enhanced compared to in wild-type neurons

enhanced long-term potentiation ( J:164681 )

• in CA2 neurons following high-frequency stimulation (HFS)

• long term potentiation (LTP) in CA1 neurons assessed in field potentials is normal and U0126 treatment restores normal LTP following HFS

behavior/neurological

behavior/neurological phenotype ( J:164681 )

N • mice exhibit normal swim speed, ambulation, baseline startle response, and anxiety in the elevated plus maze

enhanced long-term object recognition memory ( J:164681 )

• after 4 hours, mice spend more time exploring and make more contacts with a novel object indicating enhanced recognition memory compared with wild-type mice

abnormal spatial learning ( J:164681 )

• mice exhibit enhanced initial learning rate in a Morris water maze that is sustained each day compared with wild-type mice

abnormal response to novel object ( J:164681 )

• after 4 hours, mice spend more time exploring and make more contacts with a novel object indicating enhanced recognition memory compared with wild-type mice

Genotype
MGI:3609690

hm2

• Allelic Composition: Rgs14^tm1Lex/Rgs14^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd

reproductive system

reproductive system phenotype ( J:103485 )

N • mice exhibit normal fertility

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:103485 )

N • mice exhibit normal blood chemistry, urine content, and glucose homeostasis

cardiovascular system

cardiovascular system phenotype ( J:103485 )

N • mice exhibit normal blood pressure and heart rate

hematopoietic system

hematopoietic system phenotype ( J:103485 )

N • mice exhibit normal hematology

immune system

immune system phenotype ( J:103485 )

N • mice exhibit normal immune response to LPS and ovalbumin

N • ice exhibit normal T cell morphology

behavior/neurological

behavior/neurological phenotype ( J:103485 )

N • mice exhibit normal general behavior, circadian rhythm, nociception, open field behavior, pre-pulse inhibition, tail suspecision behavior, and trace aversive conditioning

vision/eye

vision/eye phenotype ( J:103485 )

N • mice exhibit normal eye angiogram and fundus morphology

growth/size/body

growth/size/body region phenotype ( J:103485 )

N • mice exhibit normal body composition

skeleton

skeleton phenotype ( J:103485 )

N • mice exhibit normal bone mineral density and bone architecture

integument

integument phenotype ( J:103485 )

N • mice exhibit normal skin fibroblast proliferation