mortality/aging
• most mice die between 3 and 4 weeks of age with some mice surviving until week 13
|
• fewer than expected mice are born
|
homeostasis/metabolism
• liver phenylalanine levels are decreased compared to in wild-type mice
|
• brain dopamine levels are decreased to 20% of those in wild-type mice
|
• brain noradrenaline levels are decreased to 20% of those in wild-type mice
|
• biopterin levels are undetectable unlike in wild-type mice
• pterin levels are increased in the brain
• dihydrobiopterin levels are decreased in the liver
|
• neopterin levels are increased in the brain, liver and kidney compared to in wild-type mice
|
• brain serotonin levels are decreased to 20% of those in wild-type mice
|
behavior/neurological
• after weaning mice exhibit tremor-like symptoms in their forelegs and bradykinesia
|
bradykinesia
(
J:131376
)
• young mice and post-weaning mice exhibit bradykinesia
|
growth/size/body
• mice weigh 30% less than wild-type
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Parkinson's disease | DOID:14330 |
OMIM:PS168600 |
J:131376 |