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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sprtm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528977
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sprtm1Lex/Sprtm1Lex involves: 129S/SvEvBrd * C57BL/6J MGI:3774594


Genotype
MGI:3774594
hm1
Allelic
Composition
Sprtm1Lex/Sprtm1Lex
Genetic
Background
involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sprtm1Lex mutation (1 available); any Spr mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die between 3 and 4 weeks of age with some mice surviving until week 13
• fewer than expected mice are born

homeostasis/metabolism
• liver phenylalanine levels are decreased compared to in wild-type mice
• brain dopamine levels are decreased to 20% of those in wild-type mice
• brain noradrenaline levels are decreased to 20% of those in wild-type mice
• biopterin levels are undetectable unlike in wild-type mice
• pterin levels are increased in the brain
• dihydrobiopterin levels are decreased in the liver
• neopterin levels are increased in the brain, liver and kidney compared to in wild-type mice
• brain serotonin levels are decreased to 20% of those in wild-type mice

behavior/neurological
• after weaning mice exhibit tremor-like symptoms in their forelegs and bradykinesia
• young mice and post-weaning mice exhibit bradykinesia

growth/size/body
• mice weigh 30% less than wild-type

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease DOID:14330 OMIM:PS168600
J:131376





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory