Phenotypes associated with this allele

• Allele Symbol: Scn11a^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528983
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn11a^tm1Lex/Scn11a^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:4430303

Genotype
MGI:4430303

hm1

• Allelic Composition: Scn11a^tm1Lex/Scn11a^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal mechanical nociception ( J:157013 )

• more sensitive response of mice towards mechanical stimuli, specifically at the right side and to a lesser extent at the left side

abnormal nociception after inflammation ( J:157013 )

• a statistically significant reduction of the flinching response after a subplantar injection of a 1% formalin solution

abnormal pain threshold ( J:157013 )

• a significantly lower response to acetone exposure after spared tibial nerve injury as compared to wild-type