About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk14tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529043
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mapk14tm1Lex/Mapk14tm1Lex
Myl7tm1(cre)Krc/Myl7+ 		involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:3580021
cn2
 		Mapk14tm1Lex/Mapk14tm1Lex
Tg(Myog-cre)1Eno/0 		involves: 129S5/SvEvBrd MGI:4415790


Genotype
MGI:3580021
cn1
Allelic
Composition		 Mapk14tm1Lex/Mapk14tm1Lex
Myl7tm1(cre)Krc/Myl7+
Genetic
Background		 involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1Lex mutation (1 available); any Mapk14 mutation (43 available)
Myl7tm1(cre)Krc mutation (0 available); any Myl7 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal fetal cardiomyocyte proliferation ( J:98514 )
• homozygous mice that are heterozygous for Myl7 tm1(cre)Krc, in which cre mediated recombination is induced in cardiomyocytes, display increased mitosis in 4 day old and adult mice cardiomyocytes

muscle
abnormal fetal cardiomyocyte proliferation ( J:98514 )
• homozygous mice that are heterozygous for Myl7 tm1(cre)Krc, in which cre mediated recombination is induced in cardiomyocytes, display increased mitosis in 4 day old and adult mice cardiomyocytes

cellular
abnormal fetal cardiomyocyte proliferation ( J:98514 )
• homozygous mice that are heterozygous for Myl7 tm1(cre)Krc, in which cre mediated recombination is induced in cardiomyocytes, display increased mitosis in 4 day old and adult mice cardiomyocytes




Genotype
MGI:4415790
cn2
Allelic
Composition		 Mapk14tm1Lex/Mapk14tm1Lex
Tg(Myog-cre)1Eno/0
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk14tm1Lex mutation (1 available); any Mapk14 mutation (43 available)
Tg(Myog-cre)1Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:155408 )
N
• mice exhibit normal angiogenesis in response to endurance exercise

cellular
cellular phenotype ( J:155408 )
N
• mice exhibit normal mitochondrial biogenesis in response to endurance exercise

muscle
muscle phenotype ( J:155408 )
N
• mice exhibit normal fiber-type transformation in response to endurance exercise




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory