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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc4a11Gt(OST443317)Lex
gene trap OST443317, Lexicon Genetics
MGI:3529084
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc4a11Gt(OST443317)Lex/Slc4a11Gt(OST443317)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:4414840


Genotype
MGI:4414840
hm1
Allelic
Composition
Slc4a11Gt(OST443317)Lex/Slc4a11Gt(OST443317)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a11Gt(OST443317)Lex mutation (0 available); any Slc4a11 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Collapse of the membranous labyrinth in the crista ampullaris and macula sacule of Slc4a11Gt(OST443317)Lex/Slc4a11Gt(OST443317)Lex mice

hearing/vestibular/ear
• membranous labyrinth is collapsed
• cross sections of the crista ampullaris, macula utricle, and macula sacule are all normal
• measurable response only at the highest intensity tested, 75db
• longer response latencies
• reduced central conduction time
• reduced potentials with prolonged latencies for later peaks
• elevated thresholds

vision/eye
• basal epithelial layer more columnar than for controls
• basal layer cell height higher than for controls
• cornea otherwise normal when examined under broad beam illumination





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory