Phenotypes associated with this allele

• Allele Symbol: Slc17a7^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3529095
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc17a7^tm1Lex/Slc17a7^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609875
ht2	Slc17a7^tm1Lex/Slc17a7^+	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5141086

Genotype
MGI:3609875

hm1

• Allelic Composition: Slc17a7^tm1Lex/Slc17a7^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:103485 , J:174414 )

• homozygotes are sickly and fail to thrive by 3 to 4 weeks of age (J:103485)

• no survival beyond 4 weeks (J:174414)

growth/size/body

decreased body size ( J:103485 )

postnatal growth retardation ( J:174414 )

• born at normal frequency and indistinguishable from litter mates at birth

• growth retarded

• fail to thrive from 3rd week onward

Genotype
MGI:5141086

ht2

• Allelic Composition: Slc17a7^tm1Lex/Slc17a7⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

nervous system

abnormal excitatory postsynaptic potential ( J:174414 )

• field EPSP responses increase faster with increased signal strength than for controls

• increased response with increased signal strength fails to reach the level seen for controls

reduced long-term potentiation ( J:174414 )

• reduced LTP as a result of theta burst stimulation

• controls demonstrate a saturated response after the second series while homozygotes continue to show small increases

• maintenance is at a lower level than in controls

behavior/neurological

abnormal inhibitory learning ( J:174414 )

• initial spatial learning ability in a Morris water maze is similar to controls

• slower in relearning platform location when the platform is moved to a different quadrant