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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adcy10tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529121
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adcy10tm1Lex/Adcy10tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3038845
hm2
 		Adcy10tm1Lex/Adcy10tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609673


Genotype
MGI:3038845
hm1
Allelic
Composition		 Adcy10tm1Lex/Adcy10tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy10tm1Lex mutation (2 available); any Adcy10 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
hairpin sperm flagellum ( J:100583 )
• over time, even cAMP analog-rescued mutant sperm fold back 180 degrees until the head and midpiece form a hairpin configuration with the rest of the sperm flagellum
kinked sperm flagellum ( J:100583 )
• even after motility is restored with a cAMP analogue, ~100% of mutant sperm show flagellar angularity
• the flagellum begins to bend at the annulus (the midpiece-principal piece junction) within 10 min of isolation
abnormal sperm motility ( J:100583 )
• sperm fail to become hyperactive even after motility is restored with cAMP
asthenozoospermia ( J:88649 , J:100583 )
• mutant sperm appear able to achieve no forward movement and produce only a trembling movement of the midpiece (J:88649)
• motility could be restored in vitro by loading sperm with a cAMP analogue (J:88649)
(J:100583)
impaired sperm capacitation ( J:100583 )
• even cAMP analog-rescued mutant sperm are unable to fertilize eggs in vitro
male infertility ( J:88649 , J:100583 )
(J:88649)
(J:100583)
abnormal fertilization ( J:88649 , J:100583 )
• in an in vitro fertilization assay mutant sperm can induce cumulus release but do not produce any two-cell stage embryos (J:88649)
• restoration of sperm motility has little effect on fertility (J:100583)

cellular
hairpin sperm flagellum ( J:100583 )
• over time, even cAMP analog-rescued mutant sperm fold back 180 degrees until the head and midpiece form a hairpin configuration with the rest of the sperm flagellum
kinked sperm flagellum ( J:100583 )
• even after motility is restored with a cAMP analogue, ~100% of mutant sperm show flagellar angularity
• the flagellum begins to bend at the annulus (the midpiece-principal piece junction) within 10 min of isolation
abnormal sperm motility ( J:100583 )
• sperm fail to become hyperactive even after motility is restored with cAMP
asthenozoospermia ( J:88649 , J:100583 )
• mutant sperm appear able to achieve no forward movement and produce only a trembling movement of the midpiece (J:88649)
• motility could be restored in vitro by loading sperm with a cAMP analogue (J:88649)
(J:100583)




Genotype
MGI:3609673
hm2
Allelic
Composition		 Adcy10tm1Lex/Adcy10tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy10tm1Lex mutation (2 available); any Adcy10 mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased triglyceride level ( J:103485 )
• seen in females

cardiovascular system
increased heart rate ( J:103485 )
• slight increase seen in both males and females




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory