Phenotypes associated with this allele

• Allele Symbol: B3gnt2^{Gt(OST237555)Lex}
• Allele Name: gene trap OST237555, Lexicon Genetics
• Allele ID: MGI:3529146
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	B3gnt2^Gt(OST237555)Lex/B3gnt2^Gt(OST237555)Lex	involves: 129S5/SvEvBrd * C57BL/6N	MGI:3759758

Genotype
MGI:3759758

hm1

• Allelic Composition: B3gnt2^{Gt(OST237555)Lex}/B3gnt2^{Gt(OST237555)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell proliferation ( J:125556 )

• CD3/CD8 T cell proliferation is measurable at day 2 whereas in wild-type mice proliferation is measurable at a later time point

abnormal macrophage physiology ( J:125556 )

• F4/80+ peritoneal macrophages stimulated by LPS results in increased production of TNF-alpha, IL-1beta and IL-6 compared to in wild-type mice

increased interleukin-1 beta secretion ( J:125556 )

• F4/80+ peritoneal macrophages stimulated by LPS results in increased production of IL-1beta

increased interleukin-6 secretion ( J:125556 )

• F4/80+ peritoneal macrophages stimulated by LPS results in increased production of IL-6

increased tumor necrosis factor secretion ( J:125556 )

• F4/80+ peritoneal macrophages stimulated by LPS results in increased production of TNF-alpha

hematopoietic system

increased T cell proliferation ( J:125556 )

• CD3/CD8 T cell proliferation is measurable at day 2 whereas in wild-type mice proliferation is measurable at a later time point

abnormal macrophage physiology ( J:125556 )

• F4/80+ peritoneal macrophages stimulated by LPS results in increased production of TNF-alpha, IL-1beta and IL-6 compared to in wild-type mice

cellular

increased T cell proliferation ( J:125556 )

• CD3/CD8 T cell proliferation is measurable at day 2 whereas in wild-type mice proliferation is measurable at a later time point