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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cds2Gt(OST184358)Lex
gene trap OST184358, Lexicon Genetics
MGI:3529169
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cds2Gt(OST184358)Lex/Cds2Gt(OST184358)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609645
ht2
 		Cds2Gt(OST184358)Lex/Cds2+ involves: 129S5/SvEvBrd * C57BL/6J MGI:3609646


Genotype
MGI:3609645
hm1
Allelic
Composition		 Cds2Gt(OST184358)Lex/Cds2Gt(OST184358)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cds2Gt(OST184358)Lex mutation (2 available); any Cds2 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:103485 )
• timing of lethality not actually specified




Genotype
MGI:3609646
ht2
Allelic
Composition		 Cds2Gt(OST184358)Lex/Cds2+
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cds2Gt(OST184358)Lex mutation (2 available); any Cds2 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:103485 )
• decreased mean percentage of B cells
increased T cell number ( J:103485 )
• increased mean percentages of CD4 and CD8 cells

nervous system
enhanced sensorimotor gating ( J:103485 )
• enhanced sensorimotor gating/attention

hematopoietic system
decreased B cell number ( J:103485 )
• decreased mean percentage of B cells
increased T cell number ( J:103485 )
• increased mean percentages of CD4 and CD8 cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory