All Phenotypes Ap4b1<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ap4b1^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529172

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ap4b1^tm1Lex/Ap4b1^tm1Lex	B6.129S-Ap4b1^tm1Lex	MGI:3814230

Allelic Composition	Ap4b1^tm1Lex/Ap4b1^tm1Lex
Genetic Background	B6.129S-Ap4b1^tm1Lex

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap4b1^tm1Lex mutation (1 available); any Ap4b1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:135974 )

• mice perform significantly poorer on a rotarod compared to wild-type mice

nervous system

nervous system phenotype ( J:135974 )

N	• mice exhibit normal brain foliation and normal laminated cortical structure

abnormal Purkinje cell morphology ( J:135974 )

• sub-cellular localization of AMPA receptors is disrupted

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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