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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Enpp2tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529186
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Enpp2tm1Lex/Enpp2tm1Lex involves: 129S/SvEvBrd * C57BL/6J MGI:3688632
ht2
 		Enpp2tm1Lex/Enpp2+ involves: 129S/SvEvBrd * C57BL/6J MGI:3688635


Genotype
MGI:3688632
hm1
Allelic
Composition		 Enpp2tm1Lex/Enpp2tm1Lex
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enpp2tm1Lex mutation (2 available); any Enpp2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:103485 )
• reported to be homozygous lethal




Genotype
MGI:3688635
ht2
Allelic
Composition		 Enpp2tm1Lex/Enpp2+
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enpp2tm1Lex mutation (2 available); any Enpp2 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-6 level ( J:103485 )
• reduced serum Il6 response to LPS challenge
decreased circulating tumor necrosis factor level ( J:103485 )
• slight reduction in TNF alpha response to LPS challenge
abnormal chemokine level ( J:103485 )
• slightly reduced MCP-1 (monocyte chemotactic protein-1) response to LPS challenge
decreased susceptibility to endotoxin shock ( J:103485 )
• reduced serum Il-6 response to LPS challenge
• slightly reduced TNF alpha and MCP-1 (monocyte chemotactic protein-1) response to LPS challenge

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:103485 )
• reduced serum Il6 response to LPS challenge
decreased circulating tumor necrosis factor level ( J:103485 )
• slight reduction in TNF alpha response to LPS challenge
abnormal chemokine level ( J:103485 )
• slightly reduced MCP-1 (monocyte chemotactic protein-1) response to LPS challenge




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory