Analysis Tools
mortality/aging
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• most mice die between E9.5 and E10.5
• however, mice from parents supplemented with myo-inositol are present at a normal Mendelian ratio at weaning
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behavior/neurological
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• 63% of mice treated with pilocarpine exhibit seizures unlike similarly treated wild-type mice
• rate of pilocarpine-induced seizures is similar to in wild-type mice pre-treated with lithium
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• regardless of inositol supplementation, mice exhibit hyperactivity or stereotypy (i.e. jumping) unlike wild-type mice
• in an open-field test, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing exhibit increased distance traveled and time moving compared with wild-type mice
• however, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing do not exhibit increased number of moving episodes in an open-field test
• in a forced swim test, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing exhibit decreased immobility compared with wild-type mice
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• in an open-field test, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing exhibit increased rearing compared with wild-type mice
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• regardless of inositol supplementation, mice exhibit hyperactivity or stereotypy (i.e. jumping) unlike wild-type mice
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nervous system
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• mice exhibit normal brain morphology
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• 63% of mice treated with pilocarpine exhibit seizures unlike similarly treated wild-type mice
• rate of pilocarpine-induced seizures is similar to in wild-type mice pre-treated with lithium
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