Phenotypes associated with this allele

• Allele Symbol: Impa1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3529209
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Impa1^tm1Lex/Impa1^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:4438445

Genotype
MGI:4438445

hm1

• Allelic Composition: Impa1^tm1Lex/Impa1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:157887 )

• most mice die between E9.5 and E10.5

• however, mice from parents supplemented with myo-inositol are present at a normal Mendelian ratio at weaning

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:157887 )

• 63% of mice treated with pilocarpine exhibit seizures unlike similarly treated wild-type mice

• rate of pilocarpine-induced seizures is similar to in wild-type mice pre-treated with lithium

hyperactivity ( J:157887 )

• regardless of inositol supplementation, mice exhibit hyperactivity or stereotypy (i.e. jumping) unlike wild-type mice

• in an open-field test, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing exhibit increased distance traveled and time moving compared with wild-type mice

• however, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing do not exhibit increased number of moving episodes in an open-field test

• in a forced swim test, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing exhibit decreased immobility compared with wild-type mice

increased vertical activity ( J:157887 )

• in an open-field test, inositol-rescued mice and inositol-rescued mice supplemented with inositol prior to testing exhibit increased rearing compared with wild-type mice

increased vertical stereotypic behavior ( J:157887 )

• regardless of inositol supplementation, mice exhibit hyperactivity or stereotypy (i.e. jumping) unlike wild-type mice

nervous system

nervous system phenotype ( J:157887 )

N • mice exhibit normal brain morphology

increased susceptibility to pharmacologically induced seizures ( J:157887 )

• 63% of mice treated with pilocarpine exhibit seizures unlike similarly treated wild-type mice

• rate of pilocarpine-induced seizures is similar to in wild-type mice pre-treated with lithium