Phenotypes associated with this allele

• Allele Symbol: Kcnk16^tm1.1Lex
• Allele Name: targeted mutation 1.1, Lexicon Genetics
• Allele ID: MGI:3529263
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnk16^tm1.1Lex/Kcnk16^tm1.1Lex	B6.129S-Kcnk16^tm1.1Lex	MGI:6151448

Genotype
MGI:6151448

hm1

• Allelic Composition: Kcnk16^tm1.1Lex/Kcnk16^tm1.1Lex
• Genetic Background: B6.129S-Kcnk16^tm1.1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased insulin secretion ( J:259519 )

• enhanced second-phase of glucose-stimulated insulin secretion

• however, first-phase secretion is normal

abnormal fasting circulating glucose level ( J:259519 )

• mice are resistance to high-fat diet-induced elevation in fasting glucose levels

endocrine/exocrine glands

abnormal pancreatic beta cell physiology ( J:259519 )

• altered action potential (AP) shape in beta cells with a tendency toward AP clustering and reduced AP and after-polarization peak height with reduced interburst intervals between oscillations

increased insulin secretion ( J:259519 )

• enhanced second-phase of glucose-stimulated insulin secretion

• however, first-phase secretion is normal