Phenotypes associated with this allele

• Allele Symbol: P2rx7^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3529296
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P2rx7^tm1Lex/P2rx7^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3833842

Genotype
MGI:3833842

hm1

• Allelic Composition: P2rx7^tm1Lex/P2rx7^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:145020 )

N • no significant differences from controls were seen in spontaneous locomotor activity, in performance in an elevated plus maze, or in novelty suppressed feeding

increased compensatory feeding amount ( J:145020 )

• increased food consumption following a 24 h fast

increased coping response ( J:145020 )

• decreased immobility time in a tail suspension test and forced swim test

immune system

abnormal macrophage physiology ( J:145020 )

• no IL1B release from peritoneal macrophages primed with LPS and then stimulated with BzATP

hematopoietic system

abnormal macrophage physiology ( J:145020 )

• no IL1B release from peritoneal macrophages primed with LPS and then stimulated with BzATP