Phenotypes associated with this allele

• Allele Symbol: Aurkc^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3529317
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aurkc^tm1Lex/Aurkc^tm1Lex	B6.129S-Aurkc^tm1Lex	MGI:3822904

Genotype
MGI:3822904

hm1

• Allelic Composition: Aurkc^tm1Lex/Aurkc^tm1Lex
• Genetic Background: B6.129S-Aurkc^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:142947 )

N • sperm counts and testis weights are normal

abnormal sperm head morphology ( J:142947 )

♂ • shortened apex

abnormal acrosome morphology ( J:142947 )

♂ • malformation

detached acrosome ( J:142947 )

♂

abnormal sperm nucleus morphology ( J:142947 )

♂ • defective chromatin condensation

decreased litter size ( J:142947 )

• males produce severely reduced litter sizes

• total number of pups produced by males is significantly reduced

• 40% of males fail to produce any pups

cellular

abnormal sperm head morphology ( J:142947 )

♂ • shortened apex

abnormal acrosome morphology ( J:142947 )

♂ • malformation

detached acrosome ( J:142947 )

♂

abnormal sperm nucleus morphology ( J:142947 )

♂ • defective chromatin condensation