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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adamts5tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529332
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adamts5tm1Lex/Adamts5tm1Lex
Tg(CMV-cre)1Cgn/0 		involves: 129S5/SvEvBrd * BALB/cJ MGI:3618178
cn2
 		Adamts5tm1Lex/Adamts5tm1.1Lex
Tg(CMV-cre)1Cgn/? 		involves: 129S5/SvEvBrd * BALB/cJ MGI:3710666


Genotype
MGI:3618178
cn1
Allelic
Composition		 Adamts5tm1Lex/Adamts5tm1Lex
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Lex mutation (2 available); any Adamts5 mutation (54 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
osteoarthritis ( J:105138 )
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal

immune system
osteoarthritis ( J:105138 )
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal




Genotype
MGI:3710666
cn2
Allelic
Composition		 Adamts5tm1Lex/Adamts5tm1.1Lex
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Lex mutation (0 available); any Adamts5 mutation (54 available)
Adamts5tm1Lex mutation (2 available); any Adamts5 mutation (54 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:105138 )
N
• mice are fertile

skeleton
abnormal cartilage morphology ( J:105138 )
• aggrecan loss (as measured by loss of toiludine blue staining in the tibiofemoral joint) is significantly less (1.15+/-0.15 mean score compared to 1.94+/-0.13 in wild-type joints)
• tibial cartilage erosion is seen in 1 of 13 joints as compared to 5 of 14 wild-type joints




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory