About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adamts5tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529332
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adamts5tm1Lex/Adamts5tm1Lex
Tg(CMV-cre)1Cgn/0 		involves: 129S5/SvEvBrd * BALB/cJ MGI:3618178
cn2
 		Adamts5tm1Lex/Adamts5tm1.1Lex
Tg(CMV-cre)1Cgn/? 		involves: 129S5/SvEvBrd * BALB/cJ MGI:3710666


Genotype
MGI:3618178
cn1
Allelic
Composition		 Adamts5tm1Lex/Adamts5tm1Lex
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Lex mutation (2 available); any Adamts5 mutation (56 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
osteoarthritis ( J:105138 )
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal

immune system
osteoarthritis ( J:105138 )
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal




Genotype
MGI:3710666
cn2
Allelic
Composition		 Adamts5tm1Lex/Adamts5tm1.1Lex
Tg(CMV-cre)1Cgn/?
Genetic
Background		 involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Lex mutation (0 available); any Adamts5 mutation (56 available)
Adamts5tm1Lex mutation (2 available); any Adamts5 mutation (56 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:105138 )
N
• mice are fertile

skeleton
abnormal cartilage morphology ( J:105138 )
• aggrecan loss (as measured by loss of toiludine blue staining in the tibiofemoral joint) is significantly less (1.15+/-0.15 mean score compared to 1.94+/-0.13 in wild-type joints)
• tibial cartilage erosion is seen in 1 of 13 joints as compared to 5 of 14 wild-type joints




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory