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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(HLA-DRB1)31Dmz
transgene insertion 31, Dennis M Zaller
MGI:3529465
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0 		involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL MGI:3639133
cx2
 		H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0 		involves: 129S2/SvPas * C57BL/6 * CBA * SJL MGI:3639130


Genotype
MGI:3639133
cx1
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (83 available)
Tg(HLA-DQA1,HLA-DQB1)1Dv mutation (3 available)
Tg(HLA-DRB1)31Dmz mutation (1 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development
abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line
abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8
decreased susceptibility to autoimmune diabetes ( J:68641 )
• incidence of diabetes (blood glucose >250 mg/dl; 5/22, 23%) is lowered from incidence in MHC class II-deficient mice expressing the DQ8 transgene (73%) and similar to deficient mice transgenic for DR4

endocrine/exocrine glands
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development

hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line
abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8

digestive/alimentary system
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:68641




Genotype
MGI:3639130
cx2
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (83 available)
Tg(HLA-DRB1)31Dmz mutation (1 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development

immune system
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development
abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice
abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8
decreased susceptibility to autoimmune diabetes ( J:68641 )
• incidence of diabetes (5/20) is lower than in MHC class II-deficient mice expressing the DQ8 transgene where incidence is 3-fold higher (73%)

hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:68641 )
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice
abnormal CD8-positive, alpha beta T cell morphology ( J:68641 )
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8

digestive/alimentary system
salivary gland inflammation ( J:68641 )
• transgenic mice develop sialadenitis and severity is associated with diabetes development

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:68641




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory