Phenotypes associated with this allele

• Allele Symbol: Adcy9^{Gt(OST193739)Lex}
• Allele Name: gene trap OST193739, Lexicon Genetics
• Allele ID: MGI:3529525
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcy9^Gt(OST193739)Lex/Adcy9^Gt(OST193739)Lex	B6.129S5-Adcy9^Gt(OST193739)Lex	MGI:6276297
hm2	Adcy9^Gt(OST193739)Lex/Adcy9^Gt(OST193739)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609615

Genotype
MGI:6276297

hm1

• Allelic Composition: Adcy9^{Gt(OST193739)Lex}/Adcy9^{Gt(OST193739)Lex}
• Genetic Background: B6.129S5-Adcy9^{Gt(OST193739)Lex}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system physiology ( J:247617 )

• overall left ventricular diastolic function is abnormal, with a decrease in the early ventricular filling velocity and ventricular filling ratio

decreased heart rate ( J:247617 )

• significant bradycardia

mortality/aging

preweaning lethality, incomplete penetrance ( J:247617 )

• after backcrossing to C57BL/6J, approximately half of the expected number of homozygotes are not present at weaning age

Genotype
MGI:3609615

hm2

• Allelic Composition: Adcy9^{Gt(OST193739)Lex}/Adcy9^{Gt(OST193739)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

immune system

increased IgG1 level ( J:103485 )

• increased mean serum IgG1 in response to ovalbumin challenge

hematopoietic system

increased IgG1 level ( J:103485 )

• increased mean serum IgG1 in response to ovalbumin challenge