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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		DaglbGt(OST195261)Lex
gene trap OST195261, Lexicon Genetics
MGI:3529581
Summary 4 genotypes


Genotype
MGI:4438722
hm1
Allelic
Composition		 DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic
Background		 B6.129S5-DaglbGt(OST195261)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DaglbGt(OST195261)Lex mutation (1 available); any Daglb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid level ( J:157850 )
• 50% reduction in 2-arachidonoyl-glycerol (2-AG), an endocannabinoid, in the brain
• 90% reduction in 2-AG levels in the liver
• about a 90% reduction in arachidonic acid levels in the liver

nervous system
nervous system phenotype ( J:157850 )
N
• unlike mice null for Dagla, no defect in neuronal proliferation in the subventricular zone is detected
abnormal neuron proliferation ( J:157850 )
• decrease in proliferation in the hippocampus at 7 - 10 weeks of age

cellular
abnormal neuron proliferation ( J:157850 )
• decrease in proliferation in the hippocampus at 7 - 10 weeks of age




Genotype
MGI:5445960
hm2
Allelic
Composition		 DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DaglbGt(OST195261)Lex mutation (1 available); any Daglb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:189393 )
N
• mice exhibit normal depolarization-induced suppression of inhibition (DSI)
abnormal nervous system morphology ( J:189393 )
• mice exhibit reduced 2-arachidonoylglycerol levels in the hypothalamus compared with wild-type mice
• mice exhibit reduced anandamide levels in the hippocampus compared with wild-type mice




Genotype
MGI:4438721
ht3
Allelic
Composition		 DaglbGt(OST195261)Lex/Daglb+
Genetic
Background		 B6.129S5-DaglbGt(OST195261)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DaglbGt(OST195261)Lex mutation (1 available); any Daglb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron proliferation ( J:157850 )
• decrease in proliferation in the hippocampus at 7 - 10 weeks of age

cellular
abnormal neuron proliferation ( J:157850 )
• decrease in proliferation in the hippocampus at 7 - 10 weeks of age




Genotype
MGI:5445961
cx4
Allelic
Composition		 DaglaGt(OST288027)Lex/DaglaGt(OST288027)Lex
DaglbGt(OST195261)Lex/DaglbGt(OST195261)Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
DaglaGt(OST288027)Lex mutation (0 available); any Dagla mutation (62 available)
DaglbGt(OST195261)Lex mutation (1 available); any Daglb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system morphology ( J:189393 )
• mice exhibit reduced 2-arachidonoylglycerol levels in the cortex, cerebellum, hypothalamus and hippocampus compared with wild-type mice
• mice exhibit reduced anandamide levels in the hippocampus compared with wild-type mice




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory