Phenotypes associated with this allele

• Allele Symbol: Tg(Ins2-CDKN1B)1Maka
• Allele Name: transgene insertion 1, Masato Kasuga
• Allele ID: MGI:3529600
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ins2-CDKN1B)1Maka/0	involves: C57BL/6J	MGI:3529603

Genotype
MGI:3529603

tg1

• Allelic Composition: Tg(Ins2-CDKN1B)1Maka/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:96047 )

• total islet mass and islet density are decreased by 8 weeks of age

decreased pancreatic beta cell number ( J:96047 )

• by 8 weeks of age the number of beta cells is decreased; however, the size of individual beta cells is normal

• proliferation of beta cells is inhibited in 8 week old transgenic mice

homeostasis/metabolism

hyperglycemia ( J:96047 )

• hyperglycemia was seen by 4 weeks of age and progressed to severe diabetes

decreased circulating insulin level ( J:96047 )

• serum insulin decreases during the development of diabetes