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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Uchl5Gt(OST447189)Lex
gene trap OST447189, Lexicon Genetics
MGI:3529781
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Uchl5Gt(OST447189)Lex/Uchl5Gt(OST447189)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:4868238


Genotype
MGI:4868238
hm1
Allelic
Composition
Uchl5Gt(OST447189)Lex/Uchl5Gt(OST447189)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Uchl5Gt(OST447189)Lex mutation (1 available); any Uchl5 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Uchl5Gt(OST447189)Lex/Uchl5Gt(OST447189)Lex embryos show defects in brain development

mortality/aging
• mice undergo resorption as early as E8.5

nervous system
• mice exhibit disorganized neuronal growth in the forebrain, cerebellum, and midbrain with formation of irregular neuronal rosettes and folds unlike in wild-type mice
• at E13.5, mice exhibit abnormal brain development that likely results in lethality unlike in wild-type mice
• mice exhibit disorganized neuronal growth in the forebrain, cerebellum, and midbrain with formation of irregular neuronal rosettes and folds unlike in wild-type mice
• underdeveloped and disorganized at E13.5
• underdeveloped at E13.5
• underdeveloped at E13.5
• disorganized at E13.5
• at E13.5, the mesencephalic vesicle is underdeveloped compared to in wild-type mice
• disorganized at E13.5

growth/size/body

embryo

cellular
• mice exhibit disorganized neuronal growth in the forebrain, cerebellum, and midbrain with formation of irregular neuronal rosettes and folds unlike in wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory