mortality/aging
• mice undergo resorption as early as E8.5
|
nervous system
• mice exhibit disorganized neuronal growth in the forebrain, cerebellum, and midbrain with formation of irregular neuronal rosettes and folds unlike in wild-type mice
|
• at E13.5, mice exhibit abnormal brain development that likely results in lethality unlike in wild-type mice
• mice exhibit disorganized neuronal growth in the forebrain, cerebellum, and midbrain with formation of irregular neuronal rosettes and folds unlike in wild-type mice
|
• underdeveloped and disorganized at E13.5
|
• underdeveloped at E13.5
|
• underdeveloped at E13.5
|
• disorganized at E13.5
|
• at E13.5, the mesencephalic vesicle is underdeveloped compared to in wild-type mice
|
• disorganized at E13.5
|
growth/size/body
embryo
cellular
• mice exhibit disorganized neuronal growth in the forebrain, cerebellum, and midbrain with formation of irregular neuronal rosettes and folds unlike in wild-type mice
|