Phenotypes associated with this allele

• Allele Symbol: Pik3c2a^{Gt(OST288105)Lex}
• Allele Name: gene trap OST288105, Lexicon Genetics
• Allele ID: MGI:3529840
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3c2a^Gt(OST288105)Lex/Pik3c2a^Gt(OST288105)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:4941826

Genotype
MGI:4941826

hm1

• Allelic Composition: Pik3c2a^{Gt(OST288105)Lex}/Pik3c2a^{Gt(OST288105)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:169710 )

• 30% of mice die by 6 months of age

immune system

immune system phenotype ( J:169710 )

N • mice exhibit normal innate and adaptive immune functions

enlarged spleen ( J:169710 )

increased leukocyte cell number ( J:169710 )

• in the peripheral blood and spleen

increased granulocyte number ( J:169710 )

• in the peripheral blood and spleen

increased neutrophil cell number ( J:169710 )

• in the peripheral blood and spleen

increased B cell number ( J:169710 )

• in the peripheral blood and spleen

increased CD4-positive, alpha-beta T cell number ( J:169710 )

• in the peripheral blood and spleen

increased CD8-positive, alpha-beta T cell number ( J:169710 )

• in the peripheral blood and spleen

increased monocyte cell number ( J:169710 )

• in the peripheral blood and spleen

increased IgA level ( J:169710 )

• mice exhibit deposition of IgA in renal tissue unlike in wild-type mice

• mice exhibit increased IgA serum levels compared with wild-type mice

increased IgG level ( J:169710 )

• mice exhibit deposition of IgG in renal tissue unlike in wild-type mice

increased IgM level ( J:169710 )

• in the serum

increased anti-double stranded DNA antibody level ( J:169710 )

glomerulonephritis ( J:169710 )

• glomerulonephropathy

renal/urinary system

increased urine protein level ( J:169710 )

• mild at 4 to 6 weeks of age and in older mice

abnormal kidney morphology ( J:169710 )

• at 3 weeks of age, mice exhibit renal lesions unlike wild-type mice

• lesions range from minimal change nephropathy and focal segmental glomerulosclerosis in subcortical glomeruli to diffuse mesangial sclerosis of most cortical and juxtaglomerular glomeruli

• mice exhibit deposition of IgA and IgG in renal tissue unlike in wild-type mice

abnormal podocyte morphology ( J:169710 )

• at 3 weeks of age, mice exhibit a loss of or injury to podocytes unlike wild-type mice

podocyte foot process effacement ( J:169710 )

• incomplete

abnormal renal glomerulus morphology ( J:169710 )

• mice exhibit cerebriform synaptopodin-staining due to the increased mesangium and restriction of the linear synaptopodin staining to podocyte foot processes lining the visceral surface of Bowman's space unlike in wild-type mice

glomerulonephritis ( J:169710 )

• glomerulonephropathy

expanded mesangial matrix ( J:169710 )

• mice exhibit an increase in mesangium compared with wild-type mice

glomerulosclerosis ( J:169710 )

• focal segmental glomerulosclerosis

• irradiated mice reconstituted with wild-type bone marrow still exhibit glomerulosclerosis

small kidney ( J:169710 )

pale kidney ( J:169710 )

decreased creatinine clearance ( J:169710 )

kidney failure ( J:169710 )

polyuria ( J:169710 )

homeostasis/metabolism

abnormal blood homeostasis ( J:169710 )

• irradiated mice reconstituted with wild-type bone marrow still exhibit abnormal blood homeostasis (increased alkaline phosphatase, blood urea nitrogen, calcium, creatinine, phosphate, IgA, and white blood cells) compared with wild-type mice

increased circulating creatinine level ( J:169710 )

increased blood urea nitrogen level ( J:169710 )

decreased circulating bilirubin level ( J:169710 )

increased circulating cholesterol level ( J:169710 )

increased circulating phosphate level ( J:169710 )

increased circulating potassium level ( J:169710 )

increased circulating alkaline phosphatase level ( J:169710 )

increased urine protein level ( J:169710 )

• mild at 4 to 6 weeks of age and in older mice

growth/size/body

decreased lean body mass ( J:169710 )

decreased body size ( J:169710 )

decreased body weight ( J:169710 )

• at 4 to 6 weeks of age

postnatal growth retardation ( J:169710 )

enlarged spleen ( J:169710 )

adipose tissue

decreased total body fat amount ( J:169710 )

hematopoietic system

enlarged spleen ( J:169710 )

decreased erythrocyte cell number ( J:169710 )

decreased hematocrit ( J:169710 )

decreased hemoglobin content ( J:169710 )

thrombocytosis ( J:169710 )

increased mean platelet volume ( J:169710 )

increased leukocyte cell number ( J:169710 )

• in the peripheral blood and spleen

increased granulocyte number ( J:169710 )

• in the peripheral blood and spleen

increased neutrophil cell number ( J:169710 )

• in the peripheral blood and spleen

increased B cell number ( J:169710 )

• in the peripheral blood and spleen

increased CD4-positive, alpha-beta T cell number ( J:169710 )

• in the peripheral blood and spleen

increased CD8-positive, alpha-beta T cell number ( J:169710 )

• in the peripheral blood and spleen

increased monocyte cell number ( J:169710 )

• in the peripheral blood and spleen

increased IgA level ( J:169710 )

• mice exhibit deposition of IgA in renal tissue unlike in wild-type mice

• mice exhibit increased IgA serum levels compared with wild-type mice

increased IgG level ( J:169710 )

• mice exhibit deposition of IgG in renal tissue unlike in wild-type mice

increased IgM level ( J:169710 )

• in the serum