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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nba10NZB
NZB
MGI:3529870
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nba10NZB/Nba10NZB
Tlr7tm1Aki/Y
X/Yaa 		B6.Cg-Nba10NZB Tlr7tm1Aki Yaa MGI:3804683
cx2
 		Nba10NZB/Nba10NZB
X/Yaa 		C57BL/6-Nba2 Yaa MGI:3529942
cx3
 		Nba10NZB/Nba10NZB
Tg(Tnfsf13b)1Fma/0 		involves: C57BL/6 * DBA/2J * NZB MGI:3789188
ot4
 		Nba10NZB/? involves: C57BL/6 * NZB * SB/Le MGI:3529941


Genotype
MGI:3804683
cx1
Allelic
Composition		 Nba10NZB/Nba10NZB
Tlr7tm1Aki/Y
X/Yaa
Genetic
Background		 B6.Cg-Nba10NZB Tlr7tm1Aki Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10NZB mutation (1 available); any Nba10 mutation (1 available)
Tlr7tm1Aki mutation (3 available); any Tlr7 mutation (20 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased monocyte cell number ( J:137656 )
• 20% monocytosis incidence in males
• monocytosis incidence is decreased compared to C57BL/6-Nba2NZB Yaa males (71% incidence)
abnormal immune serum protein physiology ( J:137656 )
• increased production of retroviral gp70 immune complex compared to wild-type males
glomerulonephritis ( J:137656 )
• 25% incidence of lethal lupus nephritis in males by 14 months of age
• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males
• increased glomerular lesion score compared to wild-type males

renal/urinary system
glomerulonephritis ( J:137656 )
• 25% incidence of lethal lupus nephritis in males by 14 months of age
• decreased susceptibility to lupus nephritis and decreased glomerular lesion scores compared to C57BL/6-Nba2 Yaa males
• increased glomerular lesion score compared to wild-type males

hematopoietic system
increased monocyte cell number ( J:137656 )
• 20% monocytosis incidence in males
• monocytosis incidence is decreased compared to C57BL/6-Nba2NZB Yaa males (71% incidence)




Genotype
MGI:3529942
cx2
Allelic
Composition		 Nba10NZB/Nba10NZB
X/Yaa
Genetic
Background		 C57BL/6-Nba2 Yaa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10NZB mutation (1 available); any Nba10 mutation (1 available)
Yaa mutation (24 available); any Yaa mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased monocyte cell number ( J:129409 , J:137656 )
• CD11b+ monocyte numbers increase as mice age (J:129409)
• a Gr-1- monocyte subset is the dominant subset by 10 months of age (J:129409)
• increased susceptibility to monocytosis in males (J:137656)
• 71% monocytosis incidence in males (J:137656)
increased susceptibility to type III hypersensitivity reaction ( J:95829 )
• increased serum gp70 immune complex levels
abnormal immune serum protein physiology ( J:137656 )
• increased production of serum gp70 immune complex in males
increased autoantibody level ( J:137656 )
• increased anti-ribonucleoprotein production in males
increased anti-nuclear antigen antibody level ( J:95829 )
• increased anti-chromatin and anti-DNA antibodies
glomerulonephritis ( J:95829 , J:137656 )
• susceptibility to severe glomerulonephritis (J:95829)
• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)
• increased lupus nephritis score (severity) in males (J:137656)

renal/urinary system
glomerulonephritis ( J:95829 , J:137656 )
• susceptibility to severe glomerulonephritis (J:95829)
• 50% incidence of lethal lupus nephritis in males by 14 months of age (J:137656)
• increased lupus nephritis score (severity) in males (J:137656)

hematopoietic system
increased monocyte cell number ( J:129409 , J:137656 )
• CD11b+ monocyte numbers increase as mice age (J:129409)
• a Gr-1- monocyte subset is the dominant subset by 10 months of age (J:129409)
• 71% monocytosis incidence in males (J:137656)
• increased susceptibility to monocytosis in males (J:137656)




Genotype
MGI:3789188
cx3
Allelic
Composition		 Nba10NZB/Nba10NZB
Tg(Tnfsf13b)1Fma/0
Genetic
Background		 involves: C57BL/6 * DBA/2J * NZB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10NZB mutation (1 available); any Nba10 mutation (1 available)
Tg(Tnfsf13b)1Fma mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:134128 )
• increased total splenic B cell numbers
increased IgG level ( J:134128 )
• increased total serum IgG antibodies
increased IgM level ( J:134128 )
• increased total serum IgM antibodies
increased susceptibility to systemic lupus erythematosus ( J:134128 )
• increased serum IgG and IgM antibodies
• increased incidence of glomerulonephritis by 3 months of age
increased anti-double stranded DNA antibody level ( J:134128 )
• increased serum IgG anti-dsDNA Abs shows positive correlation to glomerulonephritis severity
glomerulonephritis ( J:134128 )
• increased glomerulonephritis incidence at 3 months of age

renal/urinary system
glomerulonephritis ( J:134128 )
• increased glomerulonephritis incidence at 3 months of age

hematopoietic system
increased B cell number ( J:134128 )
• increased total splenic B cell numbers
increased IgG level ( J:134128 )
• increased total serum IgG antibodies
increased IgM level ( J:134128 )
• increased total serum IgM antibodies




Genotype
MGI:3529941
ot4
Allelic
Composition		 Nba10NZB/?
Genetic
Background		 involves: C57BL/6 * NZB * SB/Le
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nba10NZB mutation (1 available); any Nba10 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to type III hypersensitivity reaction ( J:95829 )
• increased serum gp70 immune complex levels
increased anti-chromatin antibody level ( J:95829 )
• increased anti-chromatin antibodies
increased anti-double stranded DNA antibody level ( J:95829 )
• increased anti-DNA antibodies
glomerulonephritis ( J:95829 )
• susceptibility to severe glomerulonephritis

renal/urinary system
glomerulonephritis ( J:95829 )
• susceptibility to severe glomerulonephritis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory