All Phenotypes Mtor<Gt(OST92090)Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mtor^{Gt(OST92090)Lex}
gene trap OST92090, Lexicon Genetics
MGI:3529989

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtor^{Gt(OST92090)Lex}/Mtor^{Gt(OST92090)Lex}	involves: 129S5/SvEvBrd	MGI:3802637
cx2	Mtor^{Gt(OST92090)Lex}/Mtor⁺ Pten^tm1Rps/Pten⁺	involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6	MGI:4848141

Allelic Composition	Mtor^{Gt(OST92090)Lex}/Mtor^{Gt(OST92090)Lex}
Genetic Background	involves: 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtor^{Gt(OST92090)Lex} mutation (1 available); any Mtor mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent inner cell mass proliferation ( J:137592 )

• inner cell mass explants fail to expand in culture unlike wild-type explants

abnormal trophoblast giant cell morphology ( J:137592 )

• explants fail to expand in culture unlike wild-type explants

cellular

absent inner cell mass proliferation ( J:137592 )

• inner cell mass explants fail to expand in culture unlike wild-type explants

Allelic Composition	Mtor^{Gt(OST92090)Lex}/Mtor⁺ Pten^tm1Rps/Pten⁺
Genetic Background	involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtor^{Gt(OST92090)Lex} mutation (1 available); any Mtor mutation (115 available)
Pten^tm1Rps mutation (1 available); any Pten mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:144810 )

• double mutants live longer than single heterozygous Pten mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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