Phenotypes associated with this allele

• Allele Symbol: Dlc1^tm1Lec
• Allele Name: targeted mutation 1, Laboratory of Experimental Carcinogenesis
• Allele ID: MGI:3529997
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlc1^tm1Lec/Dlc1^tm1Lec	involves: 129P2/OlaHsd * C57BL/6	MGI:3530518
ht2	Dlc1^tm1Lec/Dlc1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3530522

Genotype
MGI:3530518

hm1

• Allelic Composition: Dlc1^tm1Lec/Dlc1^tm1Lec
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:96194 )

• homozygotes are obtained at E10.5 but are either absent or necrotic at E12.5

embryo

abnormal placental labyrinth vasculature morphology ( J:96194 )

• at E10.5, homozygotes display reduced vascularization of the labyrinth, with defective embryonic blood vessels that contain immature fetal erythrocytes

abnormal pharyngeal arch morphology ( J:96194 )

• at E9.5, homozygotes exhibit incomplete or distorted branchial arches

open neural tube ( J:96194 )

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:96194 )

• at E10.5, homozygotes display reduced vascularization of the labyrinth, with defective embryonic blood vessels that contain immature fetal erythrocytes

abnormal heart development ( J:96194 )

• at E9.5, homozygotes exhibit cardiac abnormalities of variable severity, ranging from incomplete formation of the chambers to distorted chamber architecture

nervous system

open neural tube ( J:96194 )

abnormal brain development ( J:96194 )

• at E9.5, homozygotes display brain abnormalities of variable severity ranging from absence of forebrain and incomplete morphogenesis of the hindbrain to an open/contorted anterior neural tube and an abnormal hindbrain with a narrow lumen and a hyperplastic neuroepithelium

abnormal forebrain development ( J:96194 )

abnormal hindbrain development ( J:96194 )

cellular

abnormal cell adhesion ( J:96194 )

• MEFs isolated from E9.5 homozygotes display reduced formation of long actin stress fibers and vinculin-rich focal adhesions

craniofacial

abnormal pharyngeal arch morphology ( J:96194 )

• at E9.5, homozygotes exhibit incomplete or distorted branchial arches

Genotype
MGI:3530522

ht2

• Allelic Composition: Dlc1^tm1Lec/Dlc1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:96194 )

• adult heterozygotes do not display any gross physical, behavioral, or histopathological abnormalities up to 7 months of age