Phenotypes associated with this allele

• Allele Symbol: Tg(Th-SNCA)5Eric
• Allele Name: transgene insertion 5, Eric K Richfield
• Allele ID: MGI:3530029
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Th-SNCA)5Eric/Tg(Th-SNCA)5Eric	involves: C57BL/6	MGI:3815302
tg2	Tg(Th-SNCA)5Eric/0	involves: C57BL/6 * C57BL/6J	MGI:6099056

Genotype
MGI:3815302

tg1

• Allelic Composition: Tg(Th-SNCA)5Eric/Tg(Th-SNCA)5Eric
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal microglial cell physiology ( J:140907 )

• at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice

• however, the total number of microglial cells is normal

nervous system

abnormal microglial cell physiology ( J:140907 )

• at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice

• however, the total number of microglial cells is normal

hematopoietic system

abnormal microglial cell physiology ( J:140907 )

• at 1 month of age, mice exhibit an increase in activated microglial cells in the substantia nigra compared to in wild-type mice

• however, the total number of microglial cells is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:140907

Genotype
MGI:6099056

tg2

• Allelic Composition: Tg(Th-SNCA)5Eric/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

behavior/neurological

decreased locomotor activity ( J:96494 )

♂ • locomotor activity is 78% of littermate controls by 21-23 months of age

♂ • treatment with apomorphine has little impact on locomotor activity in mutants compared to a decrease in control littermates

homeostasis/metabolism

decreased dopamine level ( J:96494 )

♂ • mice exposed to combined pesticides show a slight decrease (18%) in dopamine levels compared to littermate controls (3%)

increased physiological sensitivity to xenobiotic ( J:96494 )

♂ • mice exposed to combined pesticides show a slight decrease (18%) in dopamine levels compared to littermate controls (3%)

nervous system

increased dopaminergic neuron number ( J:96494 )

♂ • mice show a modest but significant increase of about 10-15% in numbers of TH+ neurons in the substantia nigra pars compacta at 2.5 months of age

loss of dopaminergic neurons ( J:96494 )

♂ • mice show a significant loss of TH+ neurons across time in the substantia nigra pars compacta, with an approximate 3% loss at 8.5 months and approximate 13% loss at 19 months of age

♂ • however, inclusions are not seen in the substantia nigra pars compacta

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:96494