Phenotypes associated with this allele

• Allele Symbol: Tg(Th-SNCA*A30P*A53T)39Eric
• Allele Name: transgene insertion 39, Eric K Richfield
• Allele ID: MGI:3530031
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Th-SNCA*A30P*A53T)39Eric/0	involves: C57BL/6	MGI:3758176
tg2	Tg(Th-SNCA*A30P*A53T)39Eric/0	involves: C57BL/6 * C57BL/6J	MGI:6099058

Genotype
MGI:3758176

tg1

• Allelic Composition: Tg(Th-SNCA*A30P*A53T)39Eric/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal righting response ( J:76482 )

• 2-3 month-old mice have shorter time to right than wild-type

• with age, righting time increases significantly compared to young transgenic mice; controls do not show significant differences with age

abnormal locomotor activation ( J:76482 )

• with age (at 7-9 and 16-18 months), mice have undergone a progressive decline in locomotor activity

hyperactivity ( J:76482 )

• 2-3 month-old mice are more active relative to wild-type

nervous system

abnormal dopaminergic neuron morphology ( J:76482 )

• neurons in median forebrain bundle are more beaded and dilated in appearance compared to controls in young (2-3 months) mice

• terminals of neurons in the nucleus accumbens are abnormal with small caliber processes and dilated or enlarged terminals

homeostasis/metabolism

decreased dopamine level ( J:76482 )

• dopamine levels are lower in transgenic brains than in control brains; in aged mice, levels are signicantly lower than in 2-3 month-old transgenic mice

• similar results are seen for dopamine metabolites like DOPAC and homovanillic acid

Genotype
MGI:6099058

tg2

• Allelic Composition: Tg(Th-SNCA*A30P*A53T)39Eric/0
• Genetic Background: involves: C57BL/6 * C57BL/6J

behavior/neurological

decreased locomotor activity ( J:96494 )

♂ • locomotor activity is only 60% of littermate controls by 21-23 months of age

♂ • treatment with a high dose of apomorphine increases locomotor activity to 171% of their habituation control levels

♂ • mice exposed to progressive treatments of combined pesticides show a persistent reduction of about 70% in locomotor activity

homeostasis/metabolism

decreased dopamine level ( J:96494 )

♂ • mice exposed to combined pesticides exhibit a 56% decrease in the level of dopamine and decreased trends for its metabolites

♂ • dopamine turnover is elevated by 50% in mice exposed to combined pesticides

increased physiological sensitivity to xenobiotic ( J:96494 )

♂ • mice exposed to progressive treatments of combined pesticides show a persistent reduction of about 70% in locomotor activity

♂ • mice treated with combined pesticides show a greater loss of dopaminergic (TH+) neurons than control littermates

♂ • mice exposed to combined pesticides exhibit a 56% decrease in the level of dopamine and decreased trends for its metabolites, a 40% reduction in dihydroxyphenylacetic acid (DOPAC) levels, a 20% non-statistically significant decrease in homovanillic acid, and a 50% elevation in dopamine turnover

♂ • however, no changes in 5HT levels in the striatum are seen in mice exposed to combined pesticides

nervous system

loss of dopaminergic neurons ( J:96494 )

♂ • mice show a significant loss of TH+ neurons across time in the substantia nigra pars compacta, with an approximate 19% loss at 8.5 months and approximate 55% loss at 19 months of age

♂ • however, inclusions are not seen in the substantia nigra pars compacta

♂ • mice treated with combined pesticides show a greater loss of dopaminergic (TH+) neurons than control littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:96494