growth/size/body
• at 45 weeks of age average body weight is about 33 g and 27 g for male and female homozygotes, respectively, compared to about 43 g and 34 g for male and female wild-type mice
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• after 30 weeks of age homozygotes show little or no weight gain unlike wild-type mice
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adipose tissue
• in mice older than 30 weeks, the fat volume is significantly decreased more than would be expected in proportion to the decrease in body weight
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