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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		F2rl1tm1Bpd
targeted mutation 1, Bruce P Damiano
MGI:3530061
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		F2rl1tm1Bpd/F2rl1tm1Bpd B6.129P2-F2rl1tm1Bpd MGI:4822466
hm2
 		F2rl1tm1Bpd/F2rl1tm1Bpd involves: 129P2/OlaHsd MGI:4821000
hm3
 		F2rl1tm1Bpd/F2rl1tm1Bpd involves: 129P2/OlaHsd * C57BL/6 MGI:3530651
hm4
 		F2rl1tm1Bpd/F2rl1tm1Bpd involves: 129P2/OlaHsd * C57BL/6J MGI:4821002
cx5
 		F2rl1tm1Bpd/F2rl1tm1Bpd
F3tm1.1Dwr/F3tm1.1Dwr 		B6.129-F3tm1.1Dwr F2rl1tm1Bpd MGI:4829888
cx6
 		F2rl1tm1Bpd/F2rl1tm1Bpd
Tg(MMTV-PyVT)634Mul/0 		B6.Cg-F2rl1tm1Bpd Tg(MMTV-PyVT)634Mul MGI:4821160


Genotype
MGI:4822466
hm1
Allelic
Composition		 F2rl1tm1Bpd/F2rl1tm1Bpd
Genetic
Background		 B6.129P2-F2rl1tm1Bpd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation (0 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:88245 )
N
• mice show no differences in high dose (100% lethal challenge) lipopolysaccharide (LPS)-induced inflammation and lethality compared to controls
decreased susceptibility to endotoxin shock ( J:88245 )
• mice treated with hirudin, a selective thrombin inhibitor, during LPS challenge exhibit prolonged survival time and reduced IL-6 expression compared to wild-type mice treated with hirudin

cardiovascular system
cardiovascular system phenotype ( J:135087 )
N
• retinal neoangiogenesis after oxygen induced retinopathy is similar to wild-type mice




Genotype
MGI:4821000
hm2
Allelic
Composition		 F2rl1tm1Bpd/F2rl1tm1Bpd
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation (0 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal thermal nociception ( J:127006 )
• absence of F2rl1(PAR2) agonist-induced thermal hyperalgesia
• the thermal hyperalgesia elicited by a mast-cell activator compound 48/80 is reduced in mutants compared to wild-type mice
• mutants exhibit a significantly reduced hyperalgesic response to intraplantar injection of formalin than wild-type mice but the hyperalgesia is not completely abolished




Genotype
MGI:3530651
hm3
Allelic
Composition		 F2rl1tm1Bpd/F2rl1tm1Bpd
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation (0 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased inflammatory response ( J:124648 )
• absence of human trypsin IV and rat p23 induced edema and granulocyte infiltration after intraplantar injection
increased inflammatory response ( J:96196 )
• observed a greater inflammatory response than in controls when pancreatitis was experimentally induced in mice
increased susceptibility to induced pancreatitis ( J:96196 )
• severity of experimentally induced pancreatitis was increased compared to wild-type with more acinar cell vacuolization, intralobular edema, and acinar cell necrosis and a greater inflammatory response

endocrine/exocrine glands
increased susceptibility to induced pancreatitis ( J:96196 )
• severity of experimentally induced pancreatitis was increased compared to wild-type with more acinar cell vacuolization, intralobular edema, and acinar cell necrosis and a greater inflammatory response

behavior/neurological
abnormal pain threshold ( J:124648 )
• absence of human trypsin IV and rat p23 induced thermal hyperalgesia and mechanical allodynia and hyperalgesia




Genotype
MGI:4821002
hm4
Allelic
Composition		 F2rl1tm1Bpd/F2rl1tm1Bpd
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation (0 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:96312 )
• 20% of mutants are either stillborn or found dead within 48 hours of birth compared to 8.4% of wild-type mice
postnatal lethality, incomplete penetrance ( J:96312 )
• 20% of mutants are either stillborn or found dead within 48 hours of birth compared to 8.4% of wild-type mice

cardiovascular system
abnormal systemic arterial blood pressure ( J:96312 )
• hypotensive response to SLIGRL, a F2rl1(PAR-2) selective activating peptide, is absent
• the hypotensive and bradycardic responses to SFLLRN, a nonselective receptor activating peptide, and to TFLLRNPNDK, a F2r (PAR-1) selective activating peptide, are increased compared to wild-type mice




Genotype
MGI:4829888
cx5
Allelic
Composition		 F2rl1tm1Bpd/F2rl1tm1Bpd
F3tm1.1Dwr/F3tm1.1Dwr
Genetic
Background		 B6.129-F3tm1.1Dwr F2rl1tm1Bpd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation (0 available); any F2rl1 mutation (60 available)
F3tm1.1Dwr mutation (0 available); any F3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:135087 )
N
• retinal neoangiogenesis after oxygen induced retinopathy is similar to wild-type mice with mice showing normal regrowth of the retinal vascular network under hypoxia




Genotype
MGI:4821160
cx6
Allelic
Composition		 F2rl1tm1Bpd/F2rl1tm1Bpd
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 B6.Cg-F2rl1tm1Bpd Tg(MMTV-PyVT)634Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Bpd mutation (0 available); any F2rl1 mutation (60 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal tumor vascularization ( J:138924 )
• mutants show a delayed angiogenic switch in breast tumors, with decreased vessel infiltration in and around tumors compared to Tg(MMTV-PyVT)634Mul mice

neoplasm
abnormal tumor vascularization ( J:138924 )
• mutants show a delayed angiogenic switch in breast tumors, with decreased vessel infiltration in and around tumors compared to Tg(MMTV-PyVT)634Mul mice
decreased mammary gland tumor incidence ( J:138924 )
• adenomas and mammary adenocarcinoma develop slower in mutants than in Tg(MMTV-PyVT)634Mul mice resulting in reduced metastasis
increased mammary adenocarcinoma incidence ( J:138924 )
• delay in the appearance of palpable tumors and progression of mammary adenocarcinoma compared Tg(MMTV-PyVT)634Mul mice
increased adenoma incidence ( J:138924 )
• adenomas develop at a slower rate in mutants than in Tg(MMTV-PyVT)634Mul mice

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:138924 )
• adenomas and mammary adenocarcinoma develop slower in mutants than in Tg(MMTV-PyVT)634Mul mice resulting in reduced metastasis
increased mammary adenocarcinoma incidence ( J:138924 )
• delay in the appearance of palpable tumors and progression of mammary adenocarcinoma compared Tg(MMTV-PyVT)634Mul mice

integument
decreased mammary gland tumor incidence ( J:138924 )
• adenomas and mammary adenocarcinoma develop slower in mutants than in Tg(MMTV-PyVT)634Mul mice resulting in reduced metastasis
increased mammary adenocarcinoma incidence ( J:138924 )
• delay in the appearance of palpable tumors and progression of mammary adenocarcinoma compared Tg(MMTV-PyVT)634Mul mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory