Phenotypes associated with this allele

• Allele Symbol: Otos^tm1Cham
• Allele Name: targeted mutation 1, Christian P Hamel
• Allele ID: MGI:3530083
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otos^tm1Cham/Otos^tm1Cham	involves: 129P2/OlaHsd * C57BL/6N	MGI:3530478

Genotype
MGI:3530478

hm1

• Allelic Composition: Otos^tm1Cham/Otos^tm1Cham
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal cochlea morphology ( J:96000 )

• homozygotes exhibit cochlear fibrocyte alterations

• however, hair cells and stria vascularis appear normal

abnormal type II spiral ligament fibrocytes ( J:96000 )

• type II fibrocytes display shrinkage with enlarged extracellular spaces

• type II fibrocytes also have cytoplasmic vacuoles

abnormal type IV spiral ligament fibrocytes ( J:96000 )

• type IV fibrocytes display shrinkage with enlarged extracellular spaces

decreased cochlear microphonics ( J:96000 )

• cochlear microphonic amplitudes are decreased by 78.5%

• however, the Preyer reflex and vestibular function are normal

decreased cochlear nerve compound action potential ( J:96000 )

• the compound action potential is decreased by 59.5% and the compound action potential threshold is increased

deafness ( J:96000 )

• moderate deafness, with no frequency predominance

nervous system

decreased cochlear microphonics ( J:96000 )

• cochlear microphonic amplitudes are decreased by 78.5%

• however, the Preyer reflex and vestibular function are normal

decreased cochlear nerve compound action potential ( J:96000 )

• the compound action potential is decreased by 59.5% and the compound action potential threshold is increased

skeleton

abnormal type II spiral ligament fibrocytes ( J:96000 )

• type II fibrocytes display shrinkage with enlarged extracellular spaces

• type II fibrocytes also have cytoplasmic vacuoles

abnormal type IV spiral ligament fibrocytes ( J:96000 )

• type IV fibrocytes display shrinkage with enlarged extracellular spaces