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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gjc1tm1Weil
targeted mutation 1, Reto Weiler
MGI:3530292
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gjc1tm1Weil/Gjc1tm1Weil
Tg(Nes-cre)1Kln/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3582060
cn2
 		Gjc1tm1Kwi/Gjc1tm1Weil
Tg(Nes-cre)1Kln/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3582061


Genotype
MGI:3582060
cn1
Allelic
Composition		 Gjc1tm1Weil/Gjc1tm1Weil
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Weil mutation (1 available); any Gjc1 mutation (33 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye physiology ( J:95984 )
• cone bipolar cells are present in mutants but they are void of glycine, indicating that neurotransmitter coupling between ON bipolar cells and glycinergic AII amacrine cells is disrupted in mutants
abnormal eye electrophysiology ( J:95984 )
• scotopic electroretinogram recordings in response to 20 msec white light flashes in dark-adapted mutants showed that b-wave amplitudes were smaller than in wild-type controls but a-waves did not differ, indicating a defect in the rod driven circuitry




Genotype
MGI:3582061
cn2
Allelic
Composition		 Gjc1tm1Kwi/Gjc1tm1Weil
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjc1tm1Kwi mutation (1 available); any Gjc1 mutation (33 available)
Gjc1tm1Weil mutation (1 available); any Gjc1 mutation (33 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye electrophysiology ( J:95984 )
• scotopic electroretinogram recordings in response to 20 msec white light flashes in dark-adapted mutants showed that b-wave amplitudes were 40% smaller than in wild-type controls but a-waves did not differ, indicating a defect in the rod driven circuitry




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory