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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bag3Gt(OST16086)Lex
gene trap OST16086, Lexicon Genetics
MGI:3530294
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bag3Gt(OST16086)Lex/Bag3Gt(OST16086)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3716995


Genotype
MGI:3716995
hm1
Allelic
Composition
Bag3Gt(OST16086)Lex/Bag3Gt(OST16086)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag3Gt(OST16086)Lex mutation (1 available); any Bag3 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice are dead by day 25

growth/size/body
• after 1 week of birth mice appear dwarfed
• mice fail to gain weight after day 12

muscle
• at day 20, massive amounts of apoptosis is observed in myocardial fibers
• at day 4, the Z-disk morphology is abnormal
• at day 20, massive amounts of apoptosis is observed in skeletal muscles
• at day 20, skeletal myofiber degeneration occurs without inflammation
• striking degeneration is seen in the diaphragm, soleus, and vastus intermedius muscles
• little degeneration is observed in the tibialis anterior, extensor digitorum longus, rectus femoris, vastus lateralis, and vastus medialis

cardiovascular system

respiratory system

homeostasis/metabolism

cellular
• at day 20, massive amounts of apoptosis is observed in myocardial fibers





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory