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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cyp4f13Gt(OST14770)Lex
gene trap OST14770, Lexicon Genetics
MGI:3530334
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Apoetm1Unc/Apoetm1Unc
Cyp4f13Gt(OST14770)Lex/Cyp4f13Gt(OST14770)Lex 		involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6 MGI:6455724
cx2
 		Apoetm1Unc/Apoe+
Cyp4f13Gt(OST14770)Lex/Cyp4f13Gt(OST14770)Lex 		involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6 MGI:6455725


Genotype
MGI:6455724
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Cyp4f13Gt(OST14770)Lex/Cyp4f13Gt(OST14770)Lex
Genetic
Background		 involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Cyp4f13Gt(OST14770)Lex mutation (1 available); any Cyp4f13 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased cholesterol efflux ( J:289999 )
• in bone marrow-derived macrophages to HDL acceptors
• however, efflux to ApoA1 is normal
decreased cholesterol level ( J:289999 )
• reduced total cholesterol and cholesterol esters in bone marrow-derived macrophages after AcLDL loading
• however, free cholesterol levels are normal

cardiovascular system
decreased susceptibility to atherosclerosis ( J:289999 )
• smaller lesions with increased necrotic area in female and male mice fed a high-fat diet

hematopoietic system
abnormal macrophage chemotaxis ( J:289999 )
• bone marrow-derived macrophages fail to exhibit an increase in migration in response to LTB4 unlike wild-type cells

cellular
abnormal macrophage chemotaxis ( J:289999 )
• bone marrow-derived macrophages fail to exhibit an increase in migration in response to LTB4 unlike wild-type cells
increased cholesterol efflux ( J:289999 )
• in bone marrow-derived macrophages to HDL acceptors
• however, efflux to ApoA1 is normal

immune system
abnormal macrophage chemotaxis ( J:289999 )
• bone marrow-derived macrophages fail to exhibit an increase in migration in response to LTB4 unlike wild-type cells




Genotype
MGI:6455725
cx2
Allelic
Composition		 Apoetm1Unc/Apoe+
Cyp4f13Gt(OST14770)Lex/Cyp4f13Gt(OST14770)Lex
Genetic
Background		 involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Cyp4f13Gt(OST14770)Lex mutation (1 available); any Cyp4f13 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:289999 )
• smaller lesions in female and male mice fed a high-fat diet




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory