Analysis Tools|
Allele Symbol Allele Name Allele ID |
Elovl6Gt(OST222498)Lex gene trap OST222498 Lexicon Genetics MGI:3530353 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neurological data suggest enhanced motor coordination in the homozygous mutant mice
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• serum cholesterol levels were reduced in female homozygous mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mutants fed a high-fat, high-sucrose diet exhibit a similar weight gain, similar increases in epididymal fat pad weight and total body weight percentages, and in enlargement of white and brown adipocytes as in wild-type mice fed this diet
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• mice are slightly, but significantly, leaner than wild-type mice despite similar daily food intake of standard chow
• however, no difference in size or appearance of adipocytes from white and brown adipose tissues is seen
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• fatty acid oxidation is reduced in primary hepatocytes
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• postprandial plasma concentrations of insulin are lower
• mutants are protected from hyperinsulinemia when fed a high-fat, high-sucrose diet
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• postprandial plasma concentrations of leptin are lower
• mutants are protected from hyperleptinemia when fed a high-fat, high-sucrose diet
• however, no differences in the amounts of plasma glucose or lipid are seen
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• mutants fed a high-fat, high sucrose-diet show decreased insulin abundance throughout a glucose tolerance test
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• increase in insulin sensitivity on a standard chow diet
• mutants are protected against high-fat, high-sucrose diet-induced insulin resistance, showing a reduction in plasma insulin compared to wild-type mice in both the fasted and fed states
• protection from diet-induced insulin resistance is more prominent during an insulin tolerance test
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• absence of elongation of C16 fatty acids to C18
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• fatty acid oxidation is reduced in primary hepatocytes
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• hepatic concentrations of stearate and oleate (18:1n-9) are lower, whereas concentrations of palmitate and palmitoleate are increased; this trend is more prominent in mice fed a fat-free, high-sucrose diet
• mice fed a fat-free, high-sucrose diet have palmitoleate, usually a minor fatty acid, as the second most abundant fatty acid in the liver
• the ratios of 18:0 and 16:1/18:1 are decreased and increased, respectively, in the livers
• the ratios of 18:1/18:0 and 16:1/16:0 are higher in the liver
• fatty acid composition of plasma follows the same trend as that of the liver
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• mutants fed the high-fat, high-sucrose diet do not exhibit the increase in hepatic diacylglycrol content that is seen in wild-type mice fed this diet
• however, hepatic total cholesterol and triglyceride levels are not different on a chow diet
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• mutants fed a high-fat, high-sucrose diet exhibit a trend toward more severe hepatosteatosis than wild-type mice
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• fatty acid synthesis and oxidation are reduced in primary hepatocytes
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• islet hypertrophy is essentially absent in the pancreas of high-fat, high-sucrose diet fed mice compared to wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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