Phenotypes associated with this allele

• Allele Symbol: Dap3^{Gt(OST147863)Lex}
• Allele Name: gene trap OST147863, Lexicon Genetics
• Allele ID: MGI:3530362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dap3^Gt(OST147863)Lex/Dap3^Gt(OST147863)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3771180

Genotype
MGI:3771180

hm1

• Allelic Composition: Dap3^{Gt(OST147863)Lex}/Dap3^{Gt(OST147863)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:129756 )

• embryos fail to progress beyond E9.5

cellular

abnormal mitochondrial morphology ( J:129756 )

• average size is 2-fold smaller than in wild-type controls

• some mitochondria have swollen cristae

• other mitochondria appear to be remnants with a collapsed appearance

• only 20% of mitochondria in the cardiac muscle have a normal morphology

decreased fibroblast apoptosis ( J:129756 )

• mouse embryonic fibroblasts are resistant to apoptosis initiated by stimulation of TNF receptors

embryo

failure of initiation of embryo turning ( J:129756 )

• embryos lack axial turning

decreased embryo size ( J:129756 )

• embryos are markedly reduced in size at E9.5

abnormal placenta size ( J:129756 )

• the placenta is smaller than wild-type controls

abnormal placenta development ( J:129756 )

• in some cases the placenta deteriorates during development

growth/size/body

decreased embryo size ( J:129756 )

• embryos are markedly reduced in size at E9.5

hematopoietic system

anemia ( J:129756 )

• all E9.5 embryos appear highly anemic