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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Inppl1tm1Glas
targeted mutation 1, David J Glass
MGI:3530363
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Inppl1tm1Glas/Inppl1tm1Glas involves: C57BL/6J MGI:3530560
ht2
Inppl1tm1Glas/Inppl1+ involves: C57BL/6J MGI:3530563


Genotype
MGI:3530560
hm1
Allelic
Composition
Inppl1tm1Glas/Inppl1tm1Glas
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inppl1tm1Glas mutation (0 available); any Inppl1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• homozygous mice showed truncated facial profile, but did not exhibit any deficits in feeding

growth/size/body
• homozygous mice showed truncated facial profile, but did not exhibit any deficits in feeding
• body weight reduction is more severe in males than in females
• no reduction in food intake is seen
• more severe reduction in males than in females
• homozygous mice were highly resistant to weight gain under a high-fat diet; however, basal metabolic rate, glucose and insulin levels and glucose and insulin tolerances were all normal

homeostasis/metabolism
• homozygous mice were highly resistant to weight gain under a high-fat diet; however, basal metabolic rate, glucose and insulin levels and glucose and insulin tolerances were all normal




Genotype
MGI:3530563
ht2
Allelic
Composition
Inppl1tm1Glas/Inppl1+
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Inppl1tm1Glas mutation (0 available); any Inppl1 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• reduction in body weight is compared to wild-type but not as severe as in homozygous mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory