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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nkd1tm1Tko
targeted mutation 1, Makoto M Taketo
MGI:3530367
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nkd1tm1Tko/Nkd1tm1Tko involves: 129X1/SvJ MGI:3531414
cx2
 		Apctm1Mmt/Apc+
Nkd1tm1Tko/Nkd1tm1Tko 		involves: 129X1/SvJ MGI:3531415


Genotype
MGI:3531414
hm1
Allelic
Composition		 Nkd1tm1Tko/Nkd1tm1Tko
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkd1tm1Tko mutation (0 available); any Nkd1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:95901 )
• the number of spermatozoan-containing tubuli per 100 tubuli is significantly reduced
small seminiferous tubules ( J:95901 )
• tubule diameter is slightly but significantly reduced

reproductive system
oligozoospermia ( J:95901 )
• sperm count is reduced by 60% compared to wild-type littermates; however, sperm motility is normal
abnormal seminiferous tubule morphology ( J:95901 )
• the number of spermatozoan-containing tubuli per 100 tubuli is significantly reduced
small seminiferous tubules ( J:95901 )
• tubule diameter is slightly but significantly reduced

cellular
oligozoospermia ( J:95901 )
• sperm count is reduced by 60% compared to wild-type littermates; however, sperm motility is normal




Genotype
MGI:3531415
cx2
Allelic
Composition		 Apctm1Mmt/Apc+
Nkd1tm1Tko/Nkd1tm1Tko
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Mmt mutation (0 available); any Apc mutation (158 available)
Nkd1tm1Tko mutation (0 available); any Nkd1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestine morphology ( J:95901 )
• the number and size distribution of small intestinal polyps is not different from mice heterozygous for Apctm1Mmt alone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory