normal phenotype
• homozygous null mice were viable and fertile and did not show any significant aberrations in the brain, kidney, or testis
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Allele Symbol Allele Name Allele ID |
Aph1ctm1.1Bdes targeted mutation 1.1, Bart De Strooper MGI:3530442 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• homozygous null mice were viable and fertile and did not show any significant aberrations in the brain, kidney, or testis
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• double homozygous null mice were viable and fertile and did not show any significant aberrations in the brain, kidney, or testis, however gamma-secretase activity in the brain stem, cerebellum, and the olfactory bulb was decreased
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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