About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gpr65tm1Witt
targeted mutation 1, Owen N Witte
MGI:3530470
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gpr65tm1Witt/Gpr65tm1Witt B6.Cg-Gpr65tm1Witt MGI:3576046
hm2
 		Gpr65tm1Witt/Gpr65tm1Witt C.Cg-Gpr65tm1Witt MGI:3576047


Genotype
MGI:3576046
hm1
Allelic
Composition		 Gpr65tm1Witt/Gpr65tm1Witt
Genetic
Background		 B6.Cg-Gpr65tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr65tm1Witt mutation (1 available); any Gpr65 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune cell physiology ( J:96112 )
• production of cAMP by total splenocytes was insensitive to pH
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes

hematopoietic system
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes




Genotype
MGI:3576047
hm2
Allelic
Composition		 Gpr65tm1Witt/Gpr65tm1Witt
Genetic
Background		 C.Cg-Gpr65tm1Witt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr65tm1Witt mutation (1 available); any Gpr65 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes

hematopoietic system
abnormal leukocyte physiology ( J:96112 )
• no pH-dependent cAMP production in thymocytes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory