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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Galr2Gt(OST105469)Lex
gene trap OST105469, Lexicon Genetics
MGI:3530476
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Galr2Gt(OST105469)Lex/Galr2Gt(OST105469)Lex B6.129S5-Galr2Gt(OST105469)Lex MGI:5613186
hm2
 		Galr2Gt(OST105469)Lex/Galr2Gt(OST105469)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609964


Genotype
MGI:5613186
hm1
Allelic
Composition		 Galr2Gt(OST105469)Lex/Galr2Gt(OST105469)Lex
Genetic
Background		 B6.129S5-Galr2Gt(OST105469)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galr2Gt(OST105469)Lex mutation (3 available); any Galr2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired conditioned place preference behavior ( J:214920 )
• mice exhibit no significant morphine conditioned place preference unlike wild-type mice

nervous system
abnormal excitatory postsynaptic potential ( J:214920 )
• mice exhibit no change in excitatory postsynaptic potential amplitude after application of galanin unlike in wild-type mice




Genotype
MGI:3609964
hm2
Allelic
Composition		 Galr2Gt(OST105469)Lex/Galr2Gt(OST105469)Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galr2Gt(OST105469)Lex mutation (3 available); any Galr2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased vertical activity ( J:103485 )
• decreased rearing response during open field and other tests

immune system
decreased B cell number ( J:103485 )
• slight decrease in the mean percentage of B cells
increased T cell number ( J:103485 )
• slight increased in the mean percentage of CD4 cells

hematopoietic system
decreased B cell number ( J:103485 )
• slight decrease in the mean percentage of B cells
increased T cell number ( J:103485 )
• slight increased in the mean percentage of CD4 cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory