Phenotypes associated with this allele

• Allele Symbol: Tg(Ckm-Mkl1)1Eno
• Allele Name: transgene insertion 1, Eric N Olson
• Allele ID: MGI:3530559
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ckm-Mkl1)1Eno/0	Not Specified	MGI:3530890

Genotype
MGI:3530890

tg1

• Allelic Composition: Tg(Ckm-Mkl1)1Eno/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Muscle fiber fibrosis in Tg(Ckm-Mkl1)1Eno/0 mice

growth/size/body

decreased body size ( J:96122 )

decreased body weight ( J:96122 )

• as a result of decreased muscle mass

postnatal growth retardation ( J:96122 )

• transgenic mice are viable but fail to thrive

muscle

decreased skeletal muscle mass ( J:96122 )

myopathy ( J:96122 )

• transgenic mice display a skeletal myopathy and hypotrophy similar to but less severe than that seen in skeletal muscle specific Srf conditional mutants

• extensive fibrosis and centrally located nuclei are seen