Phenotypes associated with this allele

• Allele Symbol: Lrp5^{Gt(OST164883)Lex}
• Allele Name: gene trap OST164883, Lexicon Genetics
• Allele ID: MGI:3530598
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrp5^Gt(OST164883)Lex/Lrp5^Gt(OST164883)Lex	involves: 129S5/SvEvBrd	MGI:4414855
hm2	Lrp5^Gt(OST164883)Lex/Lrp5^Gt(OST164883)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3778392
cx3	Lrp5^Gt(OST164883)Lex/Lrp5^+ Tspan12^tm1Wye/Tspan12^+	either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)	MGI:4414856

Genotype
MGI:4414855

hm1

• Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5^{Gt(OST164883)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:154863 )

• retinal vasculature is leaky and aberrant compared to in wild-type mice

• the inner and outer plexiform layers lack capillaries unlike in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice

blood vessel congestion ( J:154863 )

• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice

increased vascular permeability ( J:154863 )

• retinal vasculature is leaky compared to in wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:154863 )

• retinal vasculature is leaky and aberrant compared to in wild-type mice

• the inner and outer plexiform layers lack capillaries unlike in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

• mice exhibit precapillary arteriolar occlusions in the retinal vasculature unlike in wild-type mice

Genotype
MGI:3778392

hm2

• Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5^{Gt(OST164883)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

skeleton

abnormal long bone diaphysis morphology ( J:133196 )

• cortical thickness of the femoral diaphysis is decreased 11% compared to in wild-type mice

abnormal lumbar vertebrae morphology ( J:133196 )

• trabecular number and thickness of the lumbar vertebra is reduced compared to in wild-type mice

abnormal bone structure ( J:133196 )

decreased bone mineral density ( J:133196 )

• at 6 weeks of age, total and femoral cancellous and cortical bone density are 14% and 16%, respectively, lower than in wild-type mice

decreased bone mineral density of femur ( J:133196 )

• mice exhibit a 19% decrease in femoral bone density

abnormal trabecular bone morphology ( J:133196 )

• cancellous bone volume is decreased 54% in the distal femur and 38% in the lumbar vertebra compared to in wild-type mice

decreased bone mass ( J:133196 )

• mice exhibit a 30% decrease in femoral cancellous and cortical bone mass

decreased compact bone mass ( J:133196 )

• at 6 weeks of age, total and femoral cortical bone mass is 23% lower than in wild-type mice

decreased trabecular bone mass ( J:133196 )

• at 6 weeks of age, total and femoral cancellous bone mass is 21% lower than in wild-type mice

decreased bone ossification ( J:133196 )

• osteoblast surface is reduced 45% compared to in wild-type mice

• bone formation rates are lower due to a decrease in mineralization surface and mineral apposition rate

decreased bone resorption ( J:133196 )

• osteoclast surface is reduced 24% in lumbar vertebrae compared to in wild-type mice

growth/size/body

decreased body weight ( J:133196 )

• at 20 to 28 weeks of age, mice weigh 9% less than wild-type mice

Genotype
MGI:4414856

cx3

• Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5⁺; Tspan12^tm1Wye/Tspan12⁺
• Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6) or (involves: 129S5/SvEvBrd * FVB/N)

cardiovascular system

abnormal retina vasculature morphology ( J:154863 )

• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:154863 )

• at P14 and P15, retinal vertical sprouts are reduced compared to in wild-type mice

• retinal vasculature stains positive for a marker of fenestration unlike in wild-type mice