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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Isl1tm1(cre/Esr1*)Krc
targeted mutation 1, Kenneth R Chien
MGI:3530632
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Isl1tm1(cre/Esr1*)Krc/Isl1tm2Sev involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3817491


Genotype
MGI:3817491
cn1
Allelic
Composition		 Isl1tm1(cre/Esr1*)Krc/Isl1tm2Sev
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre/Esr1*)Krc mutation (1 available); any Isl1 mutation (36 available)
Isl1tm2Sev mutation (1 available); any Isl1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:141110 )
• induction of cre-recombinase expression at E11.5 leads to death of the animal during the perinatal period

nervous system
abnormal sensory neuron morphology ( J:141110 )
• the number of neurons expressing TrpVI and TrpM8 are markedly decreased in the dorsal root ganglion of E18.5 embryos that have had cre-recombinase induced at E11.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory